900MG Liposomal Sulforaphane Supplement Broccoli Extract, Liver Supplement for Antioxidant, Digestion, Cellular Health 60 Capsules

I began using this product because it's great for the kidneys and later realize that it's also helps relieve minor joint pain. Has many other benefits, and I'll definitely be reordering.

Normally, when I use a product that comes in gummy form, I check the molecular weight of the active ingredient to see if it can pass the blood/brain barrier. Some products are not meant to have that function, even if they have the ability to do so. If the active ingredient is meant to pass the BBB I will normally use those gummies for buccal or sublingual absorption. Sulforaphane is meant to pass the BBB, so it can be used for buccal or sublingual absorption. That said, this particular product has a novel liposomal delivery system. To quote the product label: "Gummie-jel's dual layer design, with a protective pectin outer layer, stabilizes the fat soluble nutrients, while enhancing absorption for effective and overall vitality." Here is all you need to know about that: "Liposomes mimic natural cell membranes and have long been investigated as drug carriers due to excellent entrapment capacity, biocompatibility and safety. Despite the success of parenteral liposomes, oral delivery of liposomes is impeded by various barriers such as instability in the gastrointestinal tract, difficulties in crossing biomembranes, and mass production problems. By modulating the compositions of the lipid bilayers and adding polymers or ligands, both the stability and permeability of liposomes can be greatly improved for oral drug delivery." It seems to me that this brand of gummie has mastered that problem very well. Its ingenious delivery system can thus be swallowed whole with the confidence that the sulphoraphane will reach the small intestine, intact, where it can then pass into the blood stream directly. The problem there is that sulforaphane is filtered through the kidneys, as it is metabolized through the mercapturic acid pathway, which involves the kidney, liver, and small intestine. That begs the question, how much of the sulforaphane actually makes it to and past the BBB? Back when I had a large laboratory where I could address that question, I would do so, but for me, the easiest thing to do is to do as I have described and absorb the ingredients sublingually and/or buccally, knowing that they have a better chance of reaching the BBB intact. I did quite a bit of research on Sulforaphane supplements about a decade after they became well known. I began taking them around 10 years ago, but even then, sulforaphane wasn't well researched. The sulforaphane I was taking was expensive and I just gave up on it for that reason. When I was offered the Nextdia brand for evaluation through the Amazon Vine program, I decided to review the literature on sulforaphane and I was surprised at the volume of recent scientific research that has been done on it since I last looked into it. I invite you to do your own research (using, of course, Google Scholar) and then go to the pages where Sulforaphane is sold on AMAZON. Amazon has a huge array of choices since I first began using the product, and the most expensive one is still the most expensive and I don't find it to be any better than this Nextdia brand. I will evaluate and research further and I will update my review here if necessary.

Good stuff. Really slow delivery. Multiple times.

Price was high.

According to label, per 2 capsules, there should be 900 mg Sulforaphane, 200 mg glucoraphanin, 150 mg myrosinase, and 15 mg black pepper extract. That would be 1265 mg for 2 capsules. Or 632.5 mg per capsule. We emptied the contents of 5 individual capsules on our mg scale and measured the weight of each. We made sure our scale is calibrated before measuring. The weights we got were 398 mg, 368 mg, 362 mg, 388 mg, and 356 mg. Any way we add any 2 capsules doesn't measure up to the label claims. That's not even to mention that none of them are even close to what they should be at 632.5 mg each. And that nothing about the weights is consistent. This also makes me question if these even have any of the ingredients that the label claims. And if they do, is there even any amount close to the amount claimed on the label. I encourage others to measure these and post their results. We won't be taking any of these as we're not even sure what's in them.

What's most interesting about this extract. It can trigger autophagy. A natural process that cleans the cells thus the body out. Studies have found it can even help flush the body of micro plastics.

Wished there were more servings per bottle.

The product is new to me. I will update my review in a week or two regarding any effects, good, bad or none. The immediate issue is the labeling. Spelling errors do not instil confidence in any product, but especially a medical product. The first line in the HOW IT WORKS section: "Sulforphan is an compound..." 2 Errors, including the product spelling itself. GAH. Also, the font size is impossible to read. The label should be recreated. I own a printshop and when customers supply files like this, I strongly encourage them to redesign. If the end customer is frustrated, the product loses chances of being purchased again. That's all for now. I will report in later when I know how the actual product works.