Doctor's Best Fisetin Supplement 100 mg for Men & Women - Brain Health & Antioxidant Support, Fisetin Capsules (as Novusetin) 100mg per Serving, Vegan, Gluten Free, Soy Free, Non GMO - 30 Veg Caps

Animal Data Shows Fisetin to be a Surprisingly Effective Senolytic It is exciting to see animal data arrive for some of the potentially senolytic compounds that may turn out to destroy enough senescent cells in mammals to be worth using as first generation rejuvenation therapies. As a reminder, the accumulation of senescent cells is one of the causes of aging; countless cells become senescent every day in our bodies, but near all are destroyed. A tiny fraction linger to cause significant harm through the inflammatory signal molecules that they secrete. If these errant cells can be removed, then inflammatory diseases and numerous aspects of aging can be turned back to some degree. The results in mice stand head and shoulders above all of the other approaches to aging in terms of reliability and breadth of benefits. Some senolytic compounds have been tested in animals, but a larger body of candidate senolytic drugs are presently only accompanied by cell study data. The ability to selectively destroy senescent cells in a petri dish does little more than indicate potential; there is a significant rate of failure in medical research and development for compounds with promising cell data, and any number of reasons as to why they may not work well enough in tissues or otherwise turn out to be infeasible for use in animals and humans. Fisetin was one such senolytic candidate with cell study data only, and I had not viewed it as a likely prospect. It is a flavonoid, and the one other well-known possibly senolytic flavonoid turned out not to be useful on its own - though it is helpful as a part of a combination treatment. Given that, results from the recent animal study of fisetin noted here greatly exceed expectations, surprisingly so. Fisetin appears about as effective in mice as any of the current top senolytics, such as the chemotherapeutics dasatinib and navitoclax. Per the data in the open access paper below, dosing with fisetin destroys 25-50% of senescent cells depending on organ and method of measurement. The dose level is large in absolute terms, as one might expect for a flavonoid. For aged mice and a one-time treatment, the researchers used 100 mg/kg daily for five days. The usual approach to scale up estimated doses from mouse studies to initial human trials leads to 500 mg per day for five days for a 60kg human. Given the wealth of new results emerging these days, it seems to me that people focused on self-experimentation, open human trials, and investigative mouse studies in this field should be moving to focus on combination therapies. Consider a combination of fisetin, dasatinib, quercetin, piperlongumine, and FOXO4-DRI - multiple different mechanisms to provoke apoptosis that are all hitting senescent cells at the same time. The goal would be to see if it is possible to engineer a significantly higher level of clearance of senescent cells than any of these senolytics can achieve on their own. This seems like a plausible goal, and may turn out to present meaningful competition to efforts such as those of Oisin Biotechnologies and other groups developing more sophisticated senolytic therapies that should have high rates of clearance. Researchers Have Discovered How to Slow Aging Quote: As people age, they accumulate damaged cells. When the cells get to a certain level of damage they go through an aging process of their own, called cellular senescence. The cells also release inflammatory factors that tell the immune system to clear those damaged cells. A younger person's immune system is healthy and is able to clear the damaged cells. But as people age, they aren't cleared as effectively. Thus they begin to accumulate, cause low-level inflammation and release enzymes that can degrade the tissue. Researchers found a natural product, called fisetin, reduces the level of these damaged cells in the body. They found this by treating mice towards the end of life with this compound and see improvement in health and lifespan. "These results suggest that we can extend the period of health, termed healthspan, even towards the end of life. But there are still many questions to address, including the right dosage, for example." One question they can now answer, however, is why haven't they done this before? There were always key limitations when it came to figuring out how a drug will act on different tissues, different cells in an aging body. Researchers didn't have a way to identify if a treatment was actually attacking the particular cells that are senescent, until now.

I take over 20 supplements. I just started taking this one a little over a year ago. I haven't been sick since. I usually get sick 2-3 times per year. I live in a household with my wife who is a grade school administrator and my grandchild. I am constantly bombarded with illness. I use this by taking 1 pill a day and have used it twice as a senolytic. To take as a senolytic I recommend using the Mayo clinics latest study on frailty which doses at 20mg per KG of body weight. For me that was a 2100mg dose. I took it in olive oil and Bioperine (black pepper extract) for increased absorption. I believe it worked to decrease senescent cells in my body. My endurance increased and my everyday aches and pains went away. During this year of no sickness I did catch something once. I felt extremely tired and was running a fever of 102 degrees. This started at 2pm and I swallowed an additional 2 fisetin tablets and another zinc pill around 6pm. I went to bed at midnight still feeling very sick and with the fever. I woke up the next day with absolutely no symptoms and not sick at all. This stuff helps your body fight off the common cold and the flu. I'm truly convinced. My wife has also taken this and she has stayed sick free as well. She caught a couple of colds but fought it off and didn't stay sick for more than a day each time. I have read a lot of articles on Fisetin as a senolytic and I would suggest anyone over the age of 40 to try it at least once. The Mayo clinic is just finishing up a clinical trial that looks promising. Please google and read as much as you can about this wonderful supplement. It's a game changer. Update 3/10/2020 - a couple of weeks ago I had another incident where I was feeling weak and coming down with something. I had a fever of 100. Took a few more fisetin and a zinc pill and the next day I was perfectly fine. My 22 year old step daughter and 18 month old grand daughter on the other hand have been sick again since my last post. I believe my combination of supplements makes me immune from catching the flu or cold. The fisetin is a very big part of it. update 9/22/20 - still sick free since my last update.

This is my first purchase of this brand and supplement. It was a good value and seems to be a quality supplement. It is easy to swallow with no aftertaste or odor, and I experienced no side effects whatsoever. I will continue to purchase them to see how many health benefits I can get from them. I would recommend them!

***** ***** ***** ***** ***** Update #1: 9-20-2012. Took my first Fisetin supplement today. About 30 minutes in, I experienced a weird feeling I have never felt before. It was like when you want to yawn a lot when you feel really burnt out and tired, and your brain needs more oxygen than it is currently getting, or just as much oxygen as possible. It was like that feeling x10, but at least it only lasted a few minutes, then completely dissipated. Shortly after that my whole brain woke up, and I could think almost as good as I ever could... I distinctly remember this, in fact, because I have been mentally sluggish the past few days, and this was the first time I was back to normal. If this sounds too good to be true, I can't help that, I am just writing what I experienced. Keep in mind that I take other supplements daily but the package was delivered in the afternoon and it was taken hours after the others. ***** ***** ***** ***** ***** Update #2: 9-23-2012. Experienced similar effects as explained above, but to a much less extent, perhaps only 1/5th the feeling I felt the first day, and anywhere from 30min to 1hr 30min after taking 1 Fisetin capsule. The 2nd day was my peak mental clarity. It was actually fairly impressive, I had fleeting moments of the most profound and broad logical applications I think I have ever been able to apply to anything in my entire life. Unfortunately, the past day or so I am back to my recently typical mentally sluggish self. I haven't been able to sleep well at all any of the nights I've taken Fisetin. I have extremely vivid and memorable dreams (not unpleasant, just vivid) and I can't seem to sleep for more than 4-5 hours per night. Again, I'm not sure if any of this is from the Fisetin but it is really the only significant thing that's changed in my diet and routine recently. I'll try to keep updating at regular intervals. ***** ***** ***** ***** ***** Update #3: 9-28-2012. Feeling great. Back to normal nights sleep. I haven't noticed the effect I felt on the first day shortly after taking the caps anymore. And while I've not had any moments of extremely sharp thinking like I had on the 2nd day, I've not noticed anytime when I am thinking slower than usual, since I got better sleep. Tomorrow, I've decided to try Fisetin sublingually as the capsules have powder which looks like it will dissolve easily under the tongue. Will report back in a week or so. ***** ***** ***** ***** ***** Update #4:10-07-2012. Sublingual administration yielded slightly increased effect, however, the increased effect effect only lasted as long as it was dissolving under my tongue (~30min-60min). Not worth it, IMHO, easier to ingest. I can't report on Fisetin anymore, I am still taking Fisetin daily, but I started taking new supplements which more noticeably enhance my mental ability (phenylalanine, tyrosine, choline, + racetams). I'll check back for other experiences, though, I'd especially like to know if anyone else felt what I felt on the 2nd day of taking Fisetin? I am unsure if I will reorder Fisetin. I have felt great, mentally, almost this whole time I've been taking Fisetin. If I go back to feeling mentally sluggish after stopping, then I will reorder, and will be more able to tell if it is the Fisetin. I'll try to remember to update, if that happens. If not, I'll wait for results of actual Fisetin studies done on live humans... ***** ***** ***** ***** ***** Doctor's Best Fisetin is currently the best deal I've found. You get 100mg Fisetin x 30 caps = 3,000mg Fisetin for $11. Swanson gives you the same amount for $17. Regarding legitimacy, I have ordered supplements from both Doctor's Best and Swanson in the past and been happy. Also, both of their Fisetin supplements do NOT come from strawberries, but from the bark/stem of Rhus Succedanea L, not that it would make any difference to your body. Why Fisetine? I heard about Fisetin on a radio show. It was for Purity Product's "37 strawberries", which contains 70mg Fisetin, which to me was the only ingredient even worth buying the supplement for. The list of potential benefits really are miraculous. Purity Products gives you 70mg x 30 caps = 2,100mg Fisetin for $47, and the other ingredients are way too commonplace for that ridiculous price. Hence, why you should always check Amazon for the active ingredient in your medications, so you don't get ripped off. I was really hoping to come here and find a plethora of reviews saying how much Fisetin helped people. I can't find legitimate reviews, anywhere... But I did enough research to convince me to at least try it for $11. I did find some less-than-encouraging information on Wikipedia, though, for example: Fisetin has not been proven to work in vivo in humans, which means these benefits haven't been shown to work live humans (yet?). PLEASE let me and everyone else know if you know of any real studies done that show it work, or if you know of any current studies going on, even. Thanks. When I'm done with this bottle I will use information like that to decide whether or not to re-order it, unless of course I can notice some benefits. ----------------------------------------------------------------------------------- My pros vs. cons list, almost entirely from Wikipedia: Benefits (major) Aside from its effects on aging, various in vitro studies have shown fisetin to exert anti-inflammatory,[4][5] anti-carcinogenic,[6][7] and antiviral[8][9][10][11] effects in different lines of culture cells. Benefit (major), Negative (minor) Fisetin was, among other flavonoids, found to be a strong topoisomerase inhibitor.[22] This effect may be responsible for both anticarcinogenic and carcinogenic potentials of the substance.[23] As DNA topoisomerase inhibitors, fisetin and other flavonoids may increase risk of infant acute myeloid leukemia, a rare disease.[24]* Benefit (minor) Chinese medicine lists rhus succedanea as having antiinflammatory, antiviral, antibacterial properties, potentially confirming some of the above benefits in vivo (in humans). Anticarcinogenic benefits not being listed here actually speaks to the legitimacy of this source, as homeopathic methods alone should not be able to confirm such benefits. Negative (major) Because in vitro experiments do not or only incompletely mimic fisetin metabolism in the body, they may not accurately reflect the actual effects of fisetin in vivo. During absorption through the small intestine and passage through the liver, fisetin and other flavonoids undergo chemical modifications such that their form in circulating blood is different from that in the original dietary source.[12] Negative (major) Whether such effects can be replicated in humans and other mammals is currently still not entirely clear and remains an issue of scientific research and debate. References: [...] 4. ^ Geraets, Liesbeth; Haegens, Astrid; Brauers, Karen; Haydock, Jane A.; Vernooy, Juanita H.J.; Wouters, Emiel F.M.; Bast, Aalt; Hageman, Geja J. (2009). "Inhibition of LPS-induced pulmonary inflammation by specific flavonoids". Biochemical and Biophysical Research Communications 382 (3): 598-603. doi:10.1016/j.bbrc.2009.03.071. PMID 19292976. 5. ^ Park, Hyo-Hyun; Lee, Soyoung; Son, Hee-Young; Park, Seung-Bin; Kim, Mi-Sun; Choi, Eun-Ju; Singh, Thoudam S. K.; Ha, Jeoung-Hee et al. (2008). "Flavonoids inhibit histamine release and expression of proinflammatory cytokines in mast cells". Archives of Pharmacal Research 31 (10): 1303-11. doi:10.1007/s12272-001-2110-5. PMID 18958421. 6. ^ Lim, D. Y.; Park, J. H. Y. (2009). "Induction of p53 contributes to apoptosis of HCT-116 human colon cancer cells induced by the dietary compound fisetin". AJP: Gastrointestinal and Liver Physiology 296 (5): G1060-8. doi:10.1152/ajpgi.90490.2008. 7. ^ Khan, N.; Afaq, F.; Syed, D. N.; Mukhtar, H. (2008). "Fisetin, a novel dietary flavonoid, causes apoptosis and cell cycle arrest in human prostate cancer LNCaP cells". Carcinogenesis 29 (5): 1049-56. doi:10.1093/carcin/bgn078. PMC 2902387. PMID 18359761.[...] 8. ^ Zandi, K.; Teoh, B. T.; Sam, S. S.; Wong, P. F.; Mustafa, M.; Abubakar, S. (2011). "Antiviral activity of four types of bioflavonoid against dengue virus type-2". Virology Journal 8: 560. doi:10.1186/1743-422X-8-560. PMC 3271998. PMID 22201648. [...]. 9. ^ Lin, Y. J.; Chang, Y. C.; Hsiao, N. W.; Hsieh, J. L.; Wang, C. Y.; Kung, S. H.; Tsai, F. J.; Lan, Y. C. et al. (2012). "Fisetin and rutin as 3C protease inhibitors of enterovirus A71". Journal of Virological Methods 182 (1-2): 93-98. doi:10.1016/j.jviromet.2012.03.020. PMID 22465253. 10. ^ Kang, S. Y.; Kang, J. Y.; Oh, M. J. (2012). "Antiviral activities of flavonoids isolated from the bark of Rhus verniciflua stokes against fish pathogenic viruses in Vitro". The Journal of Microbiology 50 (2): 293-300. doi:10.1007/s12275-012-2068-7. PMID 22538659. 11. ^ Lyu, S. Y.; Rhim, J. Y.; Park, W. B. (2005). "Antiherpetic activities of flavonoids against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in vitro". Archives of pharmacal research 28 (11): 1293-1301. PMID 16350858. 12. ^ Kroon, P. A.; Clifford, M. N.; Crozier, A.; Day, A. J.; Donovan, J. L.; Manach, C.; Williamson, G. (2004). "How should we assess the effects of exposure to dietary polyphenols in vitro?". The American journal of clinical nutrition 80 (1): 15-21. PMID 15213022. 22. ^ Olaharski, A.J.; Mondrala, S.T.; Eastmond, D.A. (2005). "Chromosomal malsegregation and micronucleus induction in vitro by the DNA topoisomerase II inhibitor fisetin". Mutation Research/Genetic Toxicology and Environmental Mutagenesis 582 (1-2): 79-86. doi:10.1016/j.mrgentox.2005.01.002. PMID 15781213. 24. ^ Spector, L. G.; Xie, Y; Robison, LL; Heerema, NA; Hilden, JM; Lange, B; Felix, CA; Davies, SM et al. (2005). "Maternal Diet and Infant Leukemia: The DNA Topoisomerase II Inhibitor Hypothesis: A Report from the Children's Oncology Group". Cancer Epidemiology Biomarkers & Prevention 14 (3): 651-5. doi:10.1158/1055-9965.EPI-04-0602. PMID 15767345. ---------------------------------------------------------------------------------- Also interesting but not necessarily influential is the most likely source of Doctor's Best Fisetin (and all other Fisetin supplements, unless specifically stated otherwise): Most likely source: Asian Wax Tree (Rhus Succedanea L) Other possible source: Asian Smoke Tree (Rhus Cotinus) Price: US $ 10 - 100 / Kilogram Type: Herbal Extract. Variety: Rhus succedanea L. Form: Powder. Part: Bark Extraction. Type: Solvent Extraction. Packaging: Drum. Place of Origin: Shaanxi China (Mainland). Grade: Pharmaceutical and food. Brand Name: Rongsheng. Model Number: 98%,99%. Molecular formula: C15H10O6. Molecular weight: 286.24. Heavy metalsmax: 10PPM. Loss On Drying: ≤1.0%. Pesticides: ≤2PPM. Microbiological plate count: 1000CFU/g. E. Coil: Negative. Salmonella: Negative. Yeast & Mold: 100CFU/g. Appearance: Yellowish, brown powder.

I did not purchase Fisetin as a nootropic but as something to possibly help with sleep and Restless Legs Syndrome. I want to share my experience to possibly help anyone dealing with Restless Legs. I have been struggling with chronic fatigue brought on by my inability to sleep because of restless legs. I have a fast COMT gene which means my body uses up dopamine very quickly, leaving me almost constantly dealing with low dopamine and serotonin. That's bad enough but the low dopamine triggers restless legs, making sleep difficult. At night I am often wakened by the need to pop more and more L-Tyrosine to increase my dopamine and stop the restless legs. After an especially bad month of out of balance electrolytes, my ability to raise my dopamine became impossible. So, after about 6 weeks of very little sleep, I realized something really bad was going on - constant fatigue, weight gain, crazy brain fog, no desire to do anything, etc. I felt that if I could just sleep, I might begin to heal and feel better. I happened to see a recommendation of Fisetin as a way to slow down a fast COMT. It looked like there were no serious side effects to worry about so I decided to give it a try. Wow! I just slept like a baby for 11 hours, and my dopamine is still going strong. This promises to be life changing for me. I am so heartened, I want to cry. Being able to sleep is like a miracle. Maybe now I can finally heal from the chronic fatigue. I sure hope so!

I used the product as instructed and it didn't make any difference in my blood pressure. I monitor my blood pressure so I knew what it was before I used this product. During and at the end of the bottle my blood pressure stayed the same.

This product was recommended to me by my Functional Medicine doctor six months ago, i bought and after a month, I noticed my hair was soft as a babies and my grey was greatly diminished I didn’t have a lot to begin with but it was noticeably prettier, light brown with red and blonde sun kissed highlights. I forgot to reorder (i take so many supplements) but started noticing my grey returning after a few months. So I’ve reordered and I will not forget again! My skin is better also. It is an interesting supplement, look it up. It’s marketed as an anti aging supplement and I am a successful example of that. If it’s making my skin and hair look and feel better, what is it doing to my insides? I’d love the heart, lungs, liver and stamina of a healthy teenager again. I just started back a few days ago, already feeling more energy. Will update if any more miracles happen. :)

I tested the product for three days using one pill per day, and did not notice any strong positive or negative effects. I then used the product following a 500mg/day for 5 days protocol. I felt fantastic those 5 days - perhaps the best I've ever felt, body felt refreshed, mentally alert (not hyper-alert), and mood was very positive. I followed the protocol with a 24 hour fast, and discontinued taking the supplement. I am a bit wary of a question regarding Proposition 65 on the product label. I could not find said warning on the bottle I purchased, but that doesn't mean I missed it. Would like to find out more regarding this issue before I re-purchase, as I'm considering following protocol again in 4-6 weeks. I'd give this product a 5-star rating after confimation that it's free of a Prop 65 warning. Update: I tried this product again, and have improved rating to 5 stars. I did not experience the same benefit as original use, however decided that Prop 65 warning is vague. I will use again.

es un antioxidante que permite o vectoriza la autofagia de células senescentes promoviendo el antienvejecimiento, tiene ademas efecto cognitivo positivo aun en edad avanzada, es un flavonoide de tipo senolitico (antianging) que proviene principalmente de fresas y manzanas, no se siente el efecto pero este seria a nivel celular, seria cosa de hacerse exámenes para comprobar el efecto antioxidante, por mi parte lo estuve tomando por varias semanas y me sentí bien

me atendeu as expectativas, tudo satisfatoriamente.

No change observed. Waste of money

It's hard to say if it did anything. Expensive for not doing anything. It might be great if you can afford several bottles.