Is it possible to use two sets of outputs - as in run the XLR outputs to the house PA and run the line outs to a keyboard amp so band can monitor?

Yes, the input signal, regardless of connector used, is present on all outputs. http://artproaudio.com/downloads/specsheets/ss_dti.pdf

does it have a ground "lift" option, switchable?

No "BUT" all outputs are ground isolated from the chassis so a "lift" switch is not necessary when using this.

I want to use my studio monitors with my Macbook Pro. What cable do I need to use to plug this into my laptop?

Hi Jason,I would use an 1/8" to XLR Male Y cable like this:http://www.amazon.com/Hosa-CYX-403M-Stereo-Breakout-Cable/dp/B000068OEP/ref=sr_1_9?m=A3QYKZ7LXW9O3&s=merchant-items&ie=UTF8&qid=1448889739&sr=1-9&keywords=hosa+1%2F8+to+xlrIf this was helpful, please consider purchasing from us. We have them both in stock and ready to ship. - Pixel Pro Audio

My single coil pups are picking up interference (nearby laptop, etc) and causing my amp to hum and click; higher gain makes it worse. will this work?

You need a ground loop isolator. Some are as cheap as $20

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ART DTI Dual Transformer Isolator Hum Eliminator

ART DTI Dual Transformer Isolator Hum Eliminator

Product ID: 3498040

Details

Brand
ART
Item Weight
0.34 Kilograms
Mounting Type
Chassis Mount
Power Source
Corded
Specification Met
UL

⚡Low insertion loss for pristine signal integrity

🎧10Hz-50kHz ultra-wide frequency response

🔇Passive isolation eliminates hum & ground loops

1161 kr

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Sold byAmazon DenmarkDelivered byDesertcartCustomer service byDesertcartReturns14 days · 30 with PRO

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Description

🎛️ Silence the noise, amplify your clarity — the ART DTI hum eliminator.

ROBUST PASSIVE DESIGN - No power needed—pure analog isolation with minimal insertion loss (0.4dB @ 100kΩ), preserving your signal’s integrity.
VERSATILE CONNECTIVITY - Supports XLR, 1/4” TRS, and RCA inputs and outputs, seamlessly integrating with any pro audio setup.
CRYSTAL CLEAR AUDIO FIDELITY - Experience ultra-flat frequency response from 10Hz to 50kHz with less than ±0.5dB variance, ensuring every detail shines through.
HUM FREE LISTENING GUARANTEED - Dual transformers fully isolate input and output grounds, eradicating annoying hum and ground-loop noise for professional-grade sound.
BUILT FOR PROFESSIONALS LOVED BY CREATORS - Top-ranked in audio transformers with a trusted 1-year warranty, making it the go-to choice for discerning audio engineers.

The ART DTI Dual Transformer Isolator Hum Eliminator is a premium passive audio interface designed to eliminate hum and ground-loop noise by isolating input and output grounds via high-performance transformers. It delivers an ultra-wide frequency response (10Hz-50kHz) with minimal distortion and low insertion loss, supporting balanced and unbalanced connections (XLR, 1/4” TRS, RCA). Ideal for professional audio setups, it ensures clean, neutral sound reproduction without power requirements.

Specifications

ASIN	B0009GUOQA
Best Sellers Rank	#52,257 in Industrial & Scientific ( See Top 100 in Industrial & Scientific ) #1 in Audio Transformers
Brand Name	ART
Customer Reviews	3.8 3.8 out of 5 stars (298)
Global Trade Identification Number	00840402016380
Item Type Name	ART DTI Dual Transformer Isolator Hum Eliminator
Item Weight	0.34 Kilograms
Manufacturer	ART
Minimum Frequency	10 Hz
Model	DTI
Mounting Type	Chassis Mount
Part Number	DTI
Power Source	Corded Electric
Specification Met	UL
UPC	840402016380
Unit Count	1.0 Count
Warranty Description	1 year.

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